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Basic Sciences

Tutorial 164

Anaesthesia & Psychiatric Drugs Part 1 – Antidepressants

Dr Helen Bromhead, Consultant Anaesthetist Royal Hampshire County Hospital, Winchester, UK

Dr Adrian Feeney, Consultant Forensic Psychiatrist Hampshire Partnership Foundation Trust, UK

Correspondence to hjbromhead@hotmail.com

14th DECEMBER 2009

Abstract

Selective serotonin reuptake inhibitors and tricyclic antidepressants should be continued throughout the perioperative period to avoid discontinuation syndrome

Serotonin syndrome, which is potentially fatal, may occur in patients on SSRIs who are given pethidine or tramadol.

Careful planning is required for patients on MAOIs.

Pethidine and indirectly acting sympathomimetics are absolutely contraindicated in patients on MAOIs.

Moclobemide is a reversible inhibitor of MAO-A which has a better safety profile than traditional MAOIs.

creative commons

This work by WFSA is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/